Deciphering the star component of skin barrier repair ｜ lysate of yeast fermentation product
Whether you are a skincare white or a senior component party.
I believe I have heard of its name:
"Schizoyeast"!
In recent years, there has been an upsurge of micro-ecological skin care in the field of skin care, among which "Schizoyeast" is the star ingredient favored by many excellent products.
Do you know the reason why it is so favored? As the first self-developed cosmetic raw material since the establishment of Perfect Academy of Biological Sciences, the crystallization of the application, industrialization and commercialization of scientific research results, what in-depth research have we conducted on it? Look down, let’s make it clear.
Through previous articles, we already know that microbial barriers are closely related to skin health:
If this first line of defense is damaged, inflammatory substances produced by pathogenic bacteria will gradually break the skin barrier defense, causing skin sensitivity, inflammation or accelerated aging.
Skin barrier
In fact, "Schizoyeast" is not a yeast. In the field of cosmetics, it mainly refers to "Bifida fermentation lysate", which is an intracellular substance obtained by splitting cells after fermentation and inactivation by Bifidobacterium, including cell wall components, cytoplasmic fragments, nucleic acids and polysaccharide complexes, etc., and has been included in the Catalogue of Used Cosmetic Raw Materials in China.
However, as the core functional ingredient in the field of biological fermentation, China’s Schizoyeast raw materials have long relied on imports, so it is imperative to break the original imprisonment and develop localized cosmetic raw materials.
Perfect independent development of the exclusive process technology, with barrier repair, anti-inflammatory, anti-oxidation, anti-ultraviolet and other effects of Schizoyeast raw materials, and completed the industrialization, it was named:
Perfectus Bio 99
(hereinafter referred to as "PB 99")
Perfect Bifidobacterium longum, which was screened from more than 2,000 strains of microorganisms, was developed through multi-dimensional research on strain characteristics, fermentation technology, bioactive components, efficacy and safety.
The results of total component analysis show that it contains rich bioactive components, which are distributed in 13 component categories, totaling 745 kinds, including nucleic acids, peptides, short peptides, amino acids, vitamins and other substances. It can act synergistically on skin flora and skin cells and effectively play a role in skin care.
By promoting the expression of antimicrobial peptides
Enhance the microbial barrier of skin
Our skin is in direct contact with external germs, why is it rarely infected?
This is because human skin produces natural antimicrobial peptides (AMPs), including Cathelicidins and Defensins. Among them, antibacterial peptide has natural broad-spectrum antibacterial activity and can inhibit the growth of pathogenic bacteria. At present, the only antibacterial peptide from human body is LL-37.
Experiments show that the perfect schizoyeast PB 99 can significantly promote the expression of glial antibacterial peptide LL-37 in 3D skin model, which is helpful to maintain the balance of skin flora, better resist the invasion of foreign pathogenic microorganisms and improve the microbial barrier function of skin.
Promote the expression of barrier protein
Enhance the physical barrier of skin
1. Promote the expression of barrier proteins
When our skin is in direct contact with the outside world, the keratin barrier plays a key role in blocking the environment. Among them, the cuticular envelope is a special structure covering the outer surface of keratinocytes, and LOR is its key component. Like steel bars and cement, they complement each other and reinforce the physical barrier of skin.
The experimental results show that the perfect yeast PB 99 can significantly promote the expression of the keratin barrier protein LOR in the 3D skin cell model, so as to enhance the protective effect of the skin physical barrier.
2. Anti-oxidation and anti-ultraviolet
External stimuli, such as ultraviolet rays, can lead to excessive production of reactive oxygen species (ROS) in the skin, and oxidative free radicals can lead to cell aging and even death, which is closely related to various skin problems such as wrinkles and inflammation. Therefore, we often associate anti-aging with sun protection and anti-oxidation.
It was found that Schizoyeast PB 99 can reduce the damage of keratinocytes under ultraviolet radiation, significantly reduce the content of oxidative free radicals in Caenorhabditis elegans and zebrafish models, inhibit the activity of oxidative free radicals, effectively alleviate the oxidative damage of skin cells under external stimulation, and maintain barrier health.
Through anti-inflammation
Enhance skin immune barrier
1. Relieve skin irritation and sensitivity
There are some receptors on the surface of our skin that can feel temperature and pain, such as capsaicin receptor (TRPV1). If it is stimulated by external environment or internal body, it will produce a tingling and burning feeling. At the same time, it will also promote the secretion of inflammatory factors, leading to local telangiectasia of the skin, showing skin inflammation, redness and other problems.
It was found that in the 3D skin inflammation model stimulated by capsaicin (CAP), Schizosaccharomyces PB 99 can significantly inhibit the effect of TRPV1, thus alleviating skin irritation and sensitivity discomfort.
2. Relieve inflammation and improve immune barrier function.
Mesocytic cells will participate in the inflammatory reaction of skin, and they will gather at the inflammatory site, and the released inflammatory mediators such as TNF-α will participate in the regulation and regulation of the inflammatory process.
The experimental results of zebrafish inflammation model showed that Schizoyeast PB 99 could significantly inhibit the aggregation of neutrophils and reduce the occurrence of inflammatory reaction. In the 3D skin inflammation model stimulated by sodium dodecyl sulfate (SLS), PB 99 can also reduce the content of TNF-α, alleviate the inflammatory reaction and improve the skin immune barrier function.
3. Promote tissue repair
In addition to restraining harmful "intruders", it is also very important to repair tissue integrity in time to restore barrier function.
The principle of wound skin healing of zebrafish is very similar to that of human body. In the experimental model of zebrafish caudal fin resection, Schizosaccharomyces PB 99 significantly accelerates the regeneration and repair of caudal fin cells, and has the ability to promote the repair of skin damaged cells.
Generally speaking, the perfect yeast raw material "Perfectus Bio 99" can improve skin problems and maintain skin health by strengthening the three barriers of the skin, exerting anti-inflammatory repair, anti-oxidation and anti-ultraviolet. Namely:
1. Promote the expression of antimicrobial peptides in keratinocytes and enhance the skin microbial barrier;
2. Promote the expression of skin barrier protein, reduce the cell damage caused by oxygen free radicals and ultraviolet radiation, and improve the physical barrier function of skin;
3. Relieve skin irritation, reduce inflammatory reaction and enhance skin immune barrier function.
Perfect will provide core raw materials and technologies for product development in the field of barrier repair and skin microecology around this research and development achievement; Concentrate on scientific research to provide consumers with scientific and efficient skin care solutions. (Contributed by Perfect Academy of Biological Sciences)
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