Most satisfied:High value, good performance, taking pictures is a surprise, Huawei old fans adapt faster

The least satisfied:It’s a pity that it’s not 5G.

Workmanship appearance:Originally torn to the standard black or rococo white, finally chose rococo white, the value is really high

Configuration performance:The battery life is at the level of a regular Snapdragon model, just over 6 hours and 20 minutes.

System fluency:Performance is not to worry about, with Hongmeng 3.1 to enjoy silky smoothness, while the animation has also been strengthened a lot, there is a more obvious detail, drop down the notification bar and then pull up the recycling when the recycling is closer to the upper left corner, observe the displacement of time will be obvious.

Photo effect:If you take a picture, try it, the most intuitive experience of telephoto is stable, unprecedented stability, followed by the telephoto photo formation rate is greatly improved, the night telephoto photo image quality can not be said to be much stronger than mate40PRO, especially the smearing feeling is much better, the main camera is also stronger than mate40PRO, mainly with the variable collar, the blurring of the picture is much stronger.

1905 movie network news The film continues to have a strong box office trend, ranking first in the single-day box office for several consecutive days, and the total box office is about to break through the 500 million mark. The film has also been officially released in Hong Kong on July 21. At the Hong Kong premiere, Johnnie To and other well-known filmmakers appeared one after another to wish the film continued the momentum of the mainland box office and achieved great results in Hong Kong.

In fact, apart from the exciting scenes, the tense plot, and the core worthy of further investigation, "Detective War" also has a unique flavor in terms of "joy". In the "Detective Return" feature clip released by the film, it is a wonderful medicine that soothes the nerves of the audience after the film war. In the clip, Li Jun, who plays the "Mad Detective", after returning to the police force, makes many netizens shout "Help" because "Detective has rolled up the police force!"

The movie "Detective War" is directed and produced by a famous Hong Kong filmmaker, supervised by Zhu Shuyi, and joined by Liu Qingyun, Lin Li,,,,,, and many other powerful stars. The film is being screened nationwide!

The genius detective also called on everyone to "roll up"

Liu Qingyun rectifies the workplace laughing and crying audience

At the end of "Detective War", "Crazy Detective" Li Jun finally returned to the police force after a life-and-death battle, became a criminal investigation consultant of O Ji, and was treated with courtesy by the police force and welcomed by all the police. However, his subsequent speech surprised everyone, because he openly said: "None of us are detective, we only need to do our best to investigate the case, and always ask ourselves if we have checked the wrong case!" Then he began to ask everyone "can’t go home, can’t see family, can’t date, can’t watch football, can’t sing K, can’t play games…" Even asked everyone to "can’t watch movies"!

This episode of "The Return of the Detective" made the audience laugh and cry directly, and they all shouted "It turns out that the detective can also be curled like this", "Sir Li himself is a genius, and he has to curl ordinary people, and he is afraid", "The police’s inner OS: Sir Li begged for mercy", and many netizens joked in the comment area: "Can’t watch a movie? Can you still watch" Detective War "?" Many people said that the seemingly neurotic Liu Qingyun in the film was "a little cute" when he rectified the workplace. I didn’t expect that the detective had such a side. Sure enough, "Mr. Liu, a citizen," has excellent acting skills.

The Hong Kong premiere of "Detective War" was attended by all the stars

Johnnie To Hong Jinbao appears on the movie platform

It is reported that "Detective Wars" held a grand premiere in Hong Kong, China on the evening of July 19. Dr. Yang Shoucheng, Chairperson of Emperor Group, and his wife, together with director and producer Wei Jiahui, producer Shao Jianqiu and Zhu Shuyi, as well as protagonists Liu Qingyun, Tang Yi, Wu Haokang, Yang Tianyu, Zhang Wenjie, Beard Tong, Zhu Luoran, Che Wanwan, Liao Jiajue, Grizzly Bear, etc. attended the premiere. The well-known Hong Kong filmmakers To Kifeng, Hong Jinbao and the queen who just won the Hong Kong Film Awards also attended the premiere, and jointly wished "Detective Wars" a good hit in Hong Kong and a big box office sale!

At the Hong Kong premiere, the director Gary Wei also revealed that he had "fallen in love at first sight" with Liu Qingyun, praising Liu Qingyun as an actor who was "unfathomable" and could still surprise him by working together after a few years. When asked if the two would have the opportunity to work together again in the future, Wei Jiahui laughed and said it would depend on Liu Qingyun’s willingness.

The movie "Detective War" is currently in theaters!

On March 14th, the highly anticipated China Home Appliances and Consumer Electronics Expo 2024 (AWE2024) was grandly held in Shanghai. As one of the three major home appliances and consumer electronics exhibitions in the world, AWE brings together the innovative achievements brought by the world’s most influential and technological enterprises. Among them, JD.com and Hisense brought 4 "Lightning New Products", including Hisense E5N-Pro, Hisense Laser TV S1, Rongsheng 517 French Sugar Cube Flat Insert Refrigerator and Hisense Fresh Air Conditioning Small Oxygen Bar X5. During the JD.com "Lightning New Product Season" event, the purchase of the same new product of AWE Hisense can enjoy multiple benefits such as 10% discount on trade-in, interest-free for up to 12 issues, and limited new products purchased at 0 yuan.

In the TV industry, the battle for image quality has never stopped. Whoever has better image quality will be recognized by more users. This "Lightning New Product" Hisense E5N-Pro is equipped with Hisense Core’s independent image quality chip and professional-grade console game adaptation, bringing a new visual experience. In terms of screen, Hisense 100E5N-Pro has achieved 704 partition dynamic light control, and a stable peak brightness of 1600nit. Compared with the previous generation of products, the light control precision has increased by 83%, making the picture more transparent, the bright scene is more shocking, and the dark field details are richer. At the same time, with the only independent image quality chip developed by Hisense in China – Xinxin AI image quality chip, it can achieve pixel-level AI fine adjustment, contrast, color, clarity and dynamic range are fully improved, the skin tone of the characters in the picture is more realistic and natural, and the face scene is wider and more three-dimensional.

Hisense E5N-Pro not only brings great image quality, but also not to be outdone in sound effects. It brings a three-dimensional theater sound field experience. It adopts a 2.1-channel independent subwoofer acoustic system. After Hisense’s unique Hi-Sound Pro Teana engine and the tuning of the Golden Ear professional team, the cinema and music hall are moved into your living room. You don’t have to go out or buy tickets. Open Hisense E5N-PRO to get the best visual and auditory experience. It is worth mentioning that Hisense E5N-Pro is equipped with four mainstream sizes, 65 inches, 75 inches, 85 inches and 100 inches respectively. The prices are 4699 yuan, 6199 yuan, 8599 yuan and 16399 yuan respectively.

At the scene, Hisense also brought the annual blockbuster new Starlight S1 series, which is equipped with a 100-inch foldable screen, which does not need to break the door and open the window, and is 100% easy to enter the house. After the diaphragm curl frame is folded, it is equivalent to half the size of a ping pong table. The Starlight S1 series has also obtained Rheinland’s 0 harmful blue light verification. Through nano-level light control technology, the Starlight S1 series effectively avoids the harmful blue light range, providing users with a more comfortable and healthy visual environment. The screen does not need to be powered on, and it really has 0 radiation. Coupled with the principle of reflection imaging, the TV picture is clearer and more natural, bringing users a more immersive movie viewing experience.

The upgrading of refrigerator technology has made "fresh" more durable. This "Lightning New Product" Rongsheng 517 French Sugar Cube Flat Insert Refrigerator attracted the attention of the audience with its Yashibai light luxury panel design and elegant and atmospheric French cloth pattern. The 598mm ultra-thin body can be flush with conventional home improvement cabinets, integrated with cabinets, beautiful and atmospheric, which not only meets consumers’ aesthetic needs for the integration of home appliances and home appliances, but also avoids bumps and is clean and does not accumulate dust. The refrigerator is loaded with the nutrition and health of the family. Rongsheng 517 French Sugar Cube Flat Insert Refrigerator is also equipped with IDP high-energy ion purification technology. With the strength of sterilization rate and net taste rate exceeding 99%, fresh vegetables and fruits are always healthy, and frozen meat and seafood will not deteriorate for a long time.

With the development of the times, contemporary people’s requirements for health and sleep quality are becoming more and more strict. This "Lightning New Product" Hisense Fresh Air Conditioning Small Oxygen Bar X5 can easily solve these problems. Using micro-positive pressure fresh air technology, the dirty air in the house, including carbon dioxide, can be discharged. Even if the doors and windows are not opened, there is still a steady stream of fresh air introduced at night, which truly achieves "oxygenation without oppression, and a deep sleep". When consumers turn on the fresh air function, the outdoor air is purified 6 times to isolate dust, PM2.5 and pollutants from the outside to ensure the cleanliness of the introduced fresh air; even if the cooling heat function is turned on, the indoor air will be filtered 4 times, truly achieving "outdoor fresh air and indoor clean air integration". The most important thing is that the Hisense Fresh Air Air Conditioning Small Oxygen Bar X5 also supports the removal of aldehyde in the drying room, which can help everyone remove aldehyde easily and quickly, more efficiently and intelligently, and the new home is also healthier.

As close partners, JD.com and Hisense have long built e-billing, service process visualization and other service projects around service timeliness, service cost, and experience improvement that users pay attention to, bringing users a more reliable and reassuring experience. Especially in 2023, the two sides will carry out in-depth cooperation around trade-in projects to promote a new service experience that integrates home appliance delivery, assembly, dismantling and collection, and achieve fruitful performance growth and general praise in the market. In the future, the two sides will deepen cooperation in products, technologies and services, and jointly explore new growth space for the home appliance industry.

JAC iC5
New car features: NEDC battery life up to 530km
IPO time: May 10

　　The Jianghuai iC5 is based on Jianghuai’s new 432 platform, and its appearance and shape are similar to the Jiayue A5 on the same platform. Its appearance is very simple and handsome, and the polyline design can be seen everywhere. In terms of size, the length, width and height of the new car are 4770/1820/1514mm respectively, and the wheelbase is 2760mm. The rear of the vehicle is clearly layered, and the opening shape on both sides of the rear insurance echoes the design of the front of the car.

　　The interior of the Jianghuai iC5 uses a black rice color scheme + chrome plating + piano paint trim to bring a good texture. The large central control screen and simple design style enhance the sense of technology in the car a lot. In terms of configuration, the car has 64-color ambient lights, as well as a powerful vehicle to everything car system. Built-in iFLYTEK intelligent voice control, can recognize a variety of dialects, and controls multimedia, navigation, telephone, air conditioning, sunroof, etc., through voice control, and also has car Wi-Fi.

　　In terms of active and passive safety configuration, the JAC iC5 high-end model features intelligent ramp assistance, body stabilization system, ABS + EBD, emergency braking assistance, adaptive cruise, lane keeping assistance, lane departure warning, traffic sign recognition, and more.

　　The new car retains the hatchback tailgate design of the Jianghuai Jiayue A5, which is rare in models of the same class. In addition, the rear air conditioner is out of trend and the rear seats are divided into 4/6 proportions. In terms of power, the Jianghuai iC5 has a maximum power of 204 horsepower and a peak torque of 340 Nm. The acceleration time of 0-100km/h is 7.6 seconds. With a 64.5kWh lithium battery, the NEDC battery life can reach 530km.

Editor’s comment:

　　The appearance of the Jianghuai iC5 is very simple and spiritual, giving people a good first impression, and I believe it will win the favor of young people. Since it is a pure electric car, the cruising range is naturally the focus of everyone’s attention. The official data of the Jianghuai iC5 is 530km (NEDC battery life), which is also good. As for the configuration, it is comparable to the Chinese brand models of the same class, and it is difficult to distinguish between the top and the bottom.

　　In the case of a relatively balanced book strength, the deciding elements also include the texture of driving and interior materials, which can only be evaluated when we get the Jianghuai iC5 test car. For Jianghuai, it is also necessary to set an attractive and competitive price for the iC5 to make up for the weakness of brand recognition.

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Zero run T03
New car features: miniature car/battery life up to 403km
IPO time: May 11

　　As early as April 10, the Zero Run T03 had been on pre-sale. The new car was positioned as a miniature pure electric vehicle, and the appearance adopted what the official called the "curved design aesthetic" style, which looked quite cute. In terms of body size, the length, width and height of the T03 were 3620/1652/1577mm respectively, and the wheelbase was 2400mm.

　　The interior design of the new car is simple, and the central control screen integrates most functions. The Zero Run T03 is quite high, such as facial recognition start system, Leap On smart car system, etc.; and the T03 has the hardware foundation of "3 cameras + 1 millimeter wave radar + 11 ultrasonic radar" and up to 10 autonomous driving auxiliary features, including: APS intelligent parking system, ACC adaptive cruise system, LDW lane departure warning system, LKA lane keeping assistance system, FCW front collision warning system, AEB automatic emergency braking system, etc.

　　In terms of power, the Zero Run T03 is equipped with the Heracles electric drive assembly independently developed by Zero Run, with a maximum power of 55kW (75Ps) and a maximum torque of 155Nm. The battery pack adopts the ternary lithium battery of Ningde era, and the energy density of the battery system is as high as 171Wh/kg. According to the previous declaration information, the battery capacity of the new car is 31kWh and 38kWh, and the corresponding NEDC cruising range is 300km and 403km respectively.

Editor’s comment:

　　The Zero Run T03 is positioned as a mini car. From the perspective of body length (3620mm), it is longer than the Euler R1 (3495mm) and BYD e1 (3465mm). In addition, the slightly square body helps to improve the head space of the second row. So the Zero Run T03 gives people the feeling of a more practical mini car.

　　At present, the Zero Running T03 has started pre-sale, and the pre-sale price after subsidy is less than 80,000 yuan. Surprisingly, its configuration is very awesome, and this level of models equipped with L2-level intelligent driving assistance is indeed rare. At the same time, the new car is also equipped with the Leap On smart car system. Most importantly, its range is enough to complete the task of daily city commuting.

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SAIC MAXUS EUNIQ 5 PLUG IN
New car features: plug-in hybrid model
IPO time: May 18

　　As a plug-in hybrid model, SAIC MAXUS EUNIQ 5 PLUG IN continues the overall shape of the EUNIQ 5, both of which also adopt a new energy design style. The closed air intake grille is embellished with blue elements, and a larger front lip is added under the front surround. The shovel-like shape highlights the movement and looks very fashionable.

　　From the side, the standard MPV style design adds a sense of style to the new car due to the use of a suspended roof. In terms of size, the length, width and height of the new car are 4825/1825/1778mm, and the wheelbase is 2800mm.

"The picture shows SAIC MAXUS EUNIQ 5"

　　In terms of the interior, the new car should still use the pure electric version of the interior layout, equipped with a 7-inch LCD instrument panel and a 12.3-inch floating touch screen, and equipped with "Zebra Zhixing System". The new car offers wireless charging, head-up display, automatic emergency braking, lane keeping assistance, panoramic imaging, panoramic sunroof and seat heating.

"The picture shows SAIC MAXUS EUNIQ 5"

　　Power is the biggest highlight of the new car. The motor of the new 1.3T engine forms a plug-in gasoline-electric hybrid power system, with a maximum engine power of 163 horsepower and a maximum motor power of 82 horsepower. The comprehensive pure electric cruising range is 64km.

Editor’s comment:

　　SAIC MAXUS EUNIQ 5 PLUG IN is a plug-in hybrid model. For many friends, it is undoubtedly a more secure choice at present, without mileage anxiety, and at the same time can be supported by relevant policies. Since it is built on the same platform as the EUNIQ 5 pure electric version, their appearance, interior and even configuration will not be significantly different. Recently, SAIC MAXUS EUNIQ 5 PLUG IN has opened pre-sale, and the new car will launch 5 models. The only suspense is the price.

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SAIC MAXUS EUNIQ 6
New car features: two power versions/power balance
IPO time: May 18

　　The SAIC MAXUS EUNIQ 6 is based on the SAIC MAXUS MERA intelligent scalable mid-size vehicle platform, which is compatible with pure electric, hybrid, and fuel powertrain layouts.

　　Among them, the EUNIQ 6 PLUG IN (hereinafter referred to as the plug-in hybrid version) adopts a new air intake grille design. The appearance of blue decorative strips emphasizes the new energy identity of the new car. At the same time, blue decoration is also added to the headlight group to highlight. In addition, the new car shape is basically the same as the fuel car, and even equipped with the same 19-inch wheels.

　　The EUNIQ 6 is a pure electric model with a more futuristic feel. The new car has cancelled the plug-in hybrid version of the air intake grille shape, and the design of the full LED headlight group has been continued, resulting in a very fashionable visual effect. In addition, the new car will also be equipped with a separately designed low wind resistance rim, and the two exhaust layouts at the tail side have been cancelled, and the chrome decoration design has been changed. In terms of size, the two models remain the same, with a length, width and height of 4735/1860/1736mm respectively, and a wheelbase of 2760mm.

　　In terms of interior layout, the two use the same design. The leather-wrapped interior with stitching process and Alcantara fabric seats enhance the texture of the vehicle, and the 12.3-inch full LCD meter, head-up display and 14-inch center console display are equipped to further enhance the technological atmosphere of the vehicle. The 14-inch central control display adopts touch design and is embedded with Zebra Zhixing Internet System 3.0, which can control air conditioning, music, navigation, sunroof opening/closing, express inquiry, weather inquiry and other functions through voice.

　　In addition, the air-conditioning control area of the new car is also integrated into the central control screen, making the center console appear very simple. However, the new car does not cancel all physical buttons, and there are necessary driving auxiliary features around the shift lever.

　　It is reported that SAIC MAXUS EUNIQ 6 will also support SAIC MAXUS’s C2B intelligent customization mode. In terms of configuration, it also provides panoramic sunroof, 64-color ambient light, electric tailgate, mobile phone wireless charger, etc. In terms of safety configuration, it provides panoramic surround view system (360-degree panoramic image + transparent chassis system), parking sentry mode, tire pressure monitoring, DRS driver identification system, and supports Face ID to start the vehicle, driver fatigue reminder, in-car environment remote monitoring, etc.

　　In terms of power, the EUNIQ 6 PLUG IN is equipped with a plug-in gasoline-electric hybrid system composed of a motor of SAIC GM’s 1.3T engine. The maximum power of the engine is 163 horsepower, the maximum power of the motor is 82 horsepower, and the comprehensive pure electric cruising range is 62km.

　　The EUNIQ 6 will be equipped with a motor with a maximum power of 177 horsepower and a peak torque of 310 Nm. The power battery is a ternary lithium battery provided by Ningde Times, with a battery capacity of 70kW · h. It has the latest generation of battery heating management system and battery management system, supports fast charging mode, and has a range of 510km under NEDC comprehensive operating conditions.

Editorial comments:

　　SAIC MAXUS EUNIQ 6 can be seen as a main force for SAIC MAXUS to enter the new energy market, as a medium-sized SUV. Thanks to the generalization of the MERA platform, the new car has adopted a more mature design style. Judging from the upcoming version, the pure electric version and the plug-in hybrid version have a double insurance feeling. For SAIC MAXUS, in addition to the strength of the product itself, it is necessary to quickly improve the brand’s recognition among consumers, which takes time to accumulate.

Wen | Fangfang, New Economic Observer Mission

On December 13, 2022, Geely Automobile officially announced that its high-end pure electric brand Extreme Krypton Automobile had secretly submitted the IPO registration documents to the US Securities and Exchange Commission on December 7. At this point, this "traditional new force" established less than two years ago began to break through the IPO.

The data shows that in 2022, a total of nearly 72,000 new cars were delivered, which further narrowed the gap with the new forces’ head camp. However, despite the rapid growth, there are many "problems" in Krypton cars compared with "Wei Xiaoli": performance loss, low gross profit margin, and doubtful high-end positioning are very prominent. Nowadays, the extremely krypton car in the initial stage of development is so eager to go public, is it really hot enough?

01, a rising star, losses.

Compared with other brands of Geely Automobile, the daily performances of Krypton Automobile, which was established in 2021, are showing its more independent existence. But no matter from the development process or business performance, we can’t put it outside Geely Automobile to observe.

Before Krypton Automobile, Geely Automobile had tried many times to transform and upgrade with electrification, but it didn’t splash much water in the new energy market.

In 2015, Geely Automobile released the new energy strategy of "Blue Geely Action" and set an extremely aggressive sales target: by 2020, the sales of new energy vehicles will account for 90% of the total sales. However, at that time, Geely Automobile bet on "oil to electricity", which led to a general market reaction. In 2019, Geely Automobile launched a geometric brand focusing on the field of high-end pure electric vehicles, which is at the same level as Lectra, and the degree of attention can be seen.

But again, the geometric brand has little thunder and rain, and has not broken out its due potential. In 2020, Geely Automobile actually sold 68,000 new energy vehicles (including Geely, Link and Geometry brands), and the proportion of new energy was only 5.15%, far from reaching the target of 90%.

Until March 2021, Geely once again launched the extremely krypton car that positioned the high-end electric vehicle market, while the geometric car returned to the mainstream mass market. Once the former came out, it quickly launched the first mass-produced new car with an average sales price of more than 300,000 yuan, and ran all the way up with the strong support of the group.

Drawing of the delivery table of the new car-making forces in 2022: New Economic Observation Mission

In 2022, Kyk 001 delivered nearly 72,000 new cars, and the average order amount reached 336,000 yuan. Especially in the fourth quarter of 2022, the sales volume of Krypton in January 2001 exceeded 10,000 vehicles for three consecutive months, which was basically able to compete with the head camp of the new forces. It is also the ever-increasing sales of Krypton 001 that makes the capital market begin to re-evaluate the prospective map of Geely Automobile’s new energy.

But the question is, is Geely’s electrification transformation really successful this time? I’m afraid it’s too early to draw a conclusion. Because cars sell well, it doesn’t mean high profitability. At this point, new forces such as "Wei Xiaoli" have already had a deep understanding.

First of all, like "Wei Xiaoli", Krypton cars sell well, but their operating conditions are not satisfactory. Geely Automobile’s interim financial report in 2022 shows that in the first half of 2021 -2022, Kyo Automobile achieved revenue of 2.868 billion yuan and 8.828 billion yuan respectively. However, under the rapid growth of revenue, the net loss is constantly expanding. In the same period, the brand’s net loss reached 1.01 billion yuan and 759 million yuan respectively. In other words, in just one and a half years, Krypton has lost 1.769 billion yuan.

The crazy "burning money" of sub-brands also directly dragged down the overall profitability of Geely Automobile. In the first half of 2021-2022, the net profit of Geely Automobile was 4.847 billion yuan and 1.552 billion yuan respectively, and the year-on-year decline rate of net profit reached 12.4% and 34.81% respectively. As for the reasons for the further expansion of losses, Geely Automobile stated directly in the financial report that the relatively high operating costs of Krypton Automobile in the early stage of development and the confirmation of share-based payment fees in the current period were one of the reasons that adversely affected the profitability of the Group during the period.

It can be said that the climbing road of Krypton automobile is based on Geely automobile’s continuous blood transfusion. Nowadays, extremely krypton cars are eager for IPO. On the one hand, it can be seen that the capital market still shows great tolerance for new forces; On the other hand, it is also the bad situation caused by the group’s long-term blood transfusion behind the crazy burning of money by extremely krypton cars, which is in urgent need of IPO financing.

02, the core indicators are not good, not as good as "Wei Xiaoli"

Geely Automobile’s explanation of the development status of Krypton automobile in the financial report also gave the latter time to change course. However, with the acceleration of the electrification transformation of traditional car companies and the crazy invasion of cross-border people such as Huawei and Xiaomi, the competition faced by extremely-krypton cars is becoming increasingly fierce, and this battle is more filled with strong smoke compared with the increasingly mature head camp of new forces.

Schematic diagram of the comparison of the revenue of the new car-making forces in the first half of 2022 Tabulation: New Economic Observation Mission

First of all, from the volume point of view, the positioning of Krypton 001 has a certain competitive relationship with "Wei Xiaoli" and so on. In recent months, it has broken the sales performance of 10,000 vehicles, posing a great threat to the models such as Weilai ET5 and Tucki P7. However, judging from the volume of both sides, the revenue of extremely-krypton cars still cannot be compared with "Wei Xiaoli". According to the data of various financial reports, in the first half of 2022, Weilai, LI and Xpeng Motors achieved revenues of 20.2 billion yuan, 18.2 billion yuan and 14.8 billion yuan respectively, while the revenue of Krypton Automobile was only 8.8 billion yuan.

Graphic tabulation of gross profit margin of the new force of making cars in the first half of 2022: new economic observation group

At the same time, judging from the gross profit margin of various companies, there is a big gap between the profitability of extremely krypton cars and the head camp of new forces. According to An Conghui, CEO of Krypton Automobile, in the first half of 2022, the gross profit margin of Krypton automobile was around 5%. In the same period, the gross profit margins of LI, Weilai and Xpeng Motors reached 22.09%, 13.8% and 11.55% respectively.

The more serious situation is that Li Xiang, the founder of LI, revealed that the company is about to reach the turning point of breakeven. Li Bin, the founder of Weilai, also said that it is expected to break even in the fourth quarter of 2023. Obviously, the first batch of new car-making forces have touched the threshold of performance and profitability, while extremely krypton cars are still struggling in the whirlpool of losses.

Despite the poor performance, the capital market’s evaluation of extremely krypton cars is not low. In August, 2021, Krypton Auto completed the Pre-A round of strategic financing of US$ 500 million (equivalent to RMB 3.24 billion), with five ecological partners including Intel Capital and Contemporary Amperex Technology Co., Limited participating. After the completion of the investment, five companies got 5.6% of the shares of Extreme Krypton Automobile, and Geely Automobile’s shareholding dropped to 48%, but it is still the single largest shareholder of Extreme Krypton Automobile. At that time, the valuation of Krypton cars had reached $9 billion.

According to informed sources, this IPO in the United States will seek a valuation of more than 10 billion US dollars, and it is planned to be listed in new york as early as the second quarter of 2023. The reason why we abandoned the HKEx and chose new york as the listing place is to seek a higher valuation.

Looking at the new force "predecessors" car companies, "Wei Xiaoli" has taken the lead in listing in the United States. It took four years, six years and five years for the three companies to go public. If Krypton can really successfully pass the IPO within the predicted time, it means creating a record of the shortest time to market for new forces. And its valuation of nearly 70 billion yuan, although there is still a certain gap with Weilai (134 billion yuan) and Ideal (156.7 billion yuan), has surpassed the current market value of 57.6 billion yuan in Xpeng Motors and the zero-running car listed in September last year (the market value as of January 13 was 26.7 billion yuan).

It can be seen that although the performance is not satisfactory, the capital market still has high hopes for extremely krypton cars. However, there is a lesson that the stock price of the zero-run car broke and fell by more than 33% on the first day of listing. It is still unknown whether the extremely-krypton car can re-sample for the listing of new forces.

03, "Benchmarking Tesla", the road to high-end is not easy.

In addition to the embarrassing status quo, the problem of the extreme krypton car is that "ambition is not worthy of ability." From the emphatic wording of "the average order amount exceeds 336,000 yuan" in the sales posters of each issue, we can see that it is imperative for extreme krypton cars to hit the high end. After all, according to the definition of "high-end models" by the Federation, the starting price of products must exceed 300,000 yuan.

However, in the upsurge of "benchmarking Tesla" on the Internet, Extreme Krypton 001 played a configuration beyond Tesla such as "712km long battery life", hoping to raise the product positioning. However, in Tesla’s repeated price reduction boom, Krypton has lost its vital price advantage. As for the level of revenue and profitability, the two are not an order of magnitude.

One of the most critical problems that hinder krypton cars from taking the high-end road is that product problems emerge one after another.

Extreme krypton cars rank first in complaints. Image source: Car Quality Network

On January 1, 2023, Extreme Krypton Automobile announced that the new Extreme Krypton 001 was officially launched, and the new car was fully upgraded at the configuration level. However, it failed to take into account the rights and interests of old car owners. Since January 2nd, there have been hundreds of complaints about "sales promise not fulfilled" in the online complaint platform, ranking first in the complaint list.

According to the old owner of Krypton 001, after the launch of the new model of 001, the "old" owners who decided in advance have received the "overlord clause" to cancel the lifetime warranty, and the related rights and interests have also shrunk. The car owners accused the car of "cutting leeks" and did not hesitate to make false marketing to harm the legitimate rights and interests of consumers.

In addition, some car owners revealed that in addition to the change of rights and interests, the car also unilaterally locked the order automatically, which was inconsistent with the information promised at the beginning, and today’s terms are even more unreasonable. As of press time, Extreme Krypton Automobile has not announced the handling results of this incident.

Complaints against extremely krypton cars (partial) Image source: Car Quality Network

The actual situation is that there is a precedent for the "false marketing" of extremely krypton cars. On New Year’s Day last year, Extreme Krypton Automobile released the rights and interests of the Spring Festival, which led to the price of new cars under the same configuration being lower than the purchase price years ago, which triggered the rights protection of old car owners. After several rounds of games, Krypton finally reached a settlement with the old car owners in the form of "returning 5,000 yuan".

Since then, Krypton 001 has also experienced various questions and problems such as "disguised price increase", "replacement of motor", "EC light-sensing canopy goods are not on the right board" and "order delay". More importantly, after the incident, the authorities never paid enough attention to the owner of the extremely krypton car. Instead, they responded indifferently by destroying misleading legends and perfunctory apologies, which made the owner even more annoyed.

As we all know, one of the biggest differences between new forces and traditional car companies is that they are good at user marketing and often play the banner of "deeply linking users" in order to win the favor of more consumers. However, judging from the company’s performance, although it classifies itself as a new force, it still has the "arrogance and prejudice" of traditional car companies in its bones. This simple and rude response has had a negative impact on the brand image.

On January 9th of this year, the second new car, Extreme Krypton 009, was officially mass-produced, and it is expected to be officially delivered in the second half of January. The new car hit the "high-end" goal again, and the prices of the two models were 499,000 yuan and 588,000 yuan respectively.

However, even Jason Lin, vice president of Extreme Smart Technology, once said, "To meet the high end, it is not how much money is used to measure the high end, but whether you can represent the most important products in that market." No matter from the perspective of copying the bottom chip of Krypton 001 completely or the battery scheme that has not been optimized and upgraded, it is obvious that Krypton 009 has not controlled the core technology well.

To add insult to injury, the problem of false propaganda of Qianqiu Kyo 001 has not been properly solved, and Kyo 009 was controversial because of the advertisement "All pets are love" on the day of listing, and finally ended up deleting the advertisement. Prior to this, Li Xiang also questioned the interior space of the extremely krypton 009 and "poured cold water" on the listing of the new car. Nowadays, Krypton 009 has not been mass-produced and delivered, and it has suffered from public opinion crises one after another. This is really not a good sign.

For a company to be listed, the establishment time is too short, the loss situation of the company is increasing, and the product quality problems have been repeatedly criticized, which will become a stumbling block on the road to sprint IPO. Whether Geely can achieve the goal of high-end by relying on Krypton 009 can be successfully achieved, I am afraid it will take a long time to investigate.

In the car home Haikou preferential promotion channel, we can see a high-profile car model-a preferential activity is under way. The starting price of this model in Haikou area is 390,900 yuan, and the highest discount is 135,000 yuan. If you are interested in this model, you can click "Check the car price" in the quotation form to get a higher discount.

The design of Volvo XC60 new energy is unique, and the front face design is fashionable. The car adopts a unique air intake grille design, which makes its overall style more refined. The body lines are smooth and full of strength. As a new energy vehicle, Volvo XC60 New Energy also has a unique logo and detailed design to show its environmental protection characteristics. The overall style is simple and generous, showing Volvo’s consistent high quality and elegant temperament.

Volvo XC60 new energy vehicle is a medium-sized SUV with a body length of 4708mm, a body width of 1902mm, a body height of 1656mm and a wheelbase of 2865 mm.. The car uses 255/45 R20 front and rear tires, with fashionable rim style and high visual impact. The body lines are smooth and exquisite, especially the design of the side lines is unique, which shows the perfect combination of luxury and sportiness. The front wheel track is 1649mm and the rear wheel track is 1653mm, which makes the vehicle more stable and better in handling.

The interior design of Volvo XC60 New Energy is simple and elegant, with attention to detail and texture. The steering wheel is made of leather, which can be manually adjusted up and down and back and forth, so that drivers can easily find the driving posture that suits them best. The central control screen has a size of 9 inches, supports voice recognition control system, and can control functions such as multimedia, navigation, telephone and air conditioning. The front and rear rows are equipped with USB/Type-C interface, which is convenient for users to charge. The front seats are also equipped with heating function, and both the driver’s seat and the co-pilot seat support power seat memory. In addition, the seat can be adjusted in front and back, backrest, height, leg rest and lumbar support to provide a comfortable riding experience. The rear seats support proportional reclining, and the space can be flexibly adjusted as needed.

Santana is a classic car with reliable quality and excellent performance. It has a maximum power of 228 kW and a maximum torque of 400 N m. It is equipped with a 2.0T 310 HP L4 engine, which provides a strong power output. At the same time, it is equipped with an 8-speed automatic gearbox, which can shift gears smoothly and quickly, making driving more comfortable. Whether on urban roads or highways, Volvo XC60 new energy can bring excellent driving experience.

As a luxury SUV, Volvo XC60 New Energy not only shows a unique design style in the appearance of the whole vehicle, but also performs well in the interior, performance and safety. Car home car owners’ evaluation of it is also very pertinent. He mentioned that although the removal of the tail throat made the back look a little bald, it was still acceptable. In addition, 24 wheels have been changed into low wind resistance shapes. Although some people don’t like them, they also have a sense of science and technology, which complements the overall style. It can be seen that the details and overall style of Volvo XC60 new energy have been recognized and affirmed by the owners. Whether on urban roads or highways, this model can provide excellent driving experience and safety guarantee. Therefore, for those consumers who pursue luxury, comfort and safety, Volvo XC60 new energy is undoubtedly a worthy choice.

Zhangjiakou car home preferential promotion channel brings you the latest preferential information! At present, the model is undergoing preferential activities, and the preferential amount is as high as 12,000 yuan. The activity covers Zhangjiakou area, and the minimum starting price is 140,900 yuan. If you are interested in this model, please click "Check Car Price" in the quotation form to get more preferential information. Act quickly, seize the opportunity and enjoy the car discount!

Tiggo 9 is a stylish SUV model, with a large air intake grille on the front face and streamlined chrome decoration, creating a strong visual impact. The body lines are smooth, and the overall style is tough and exquisite, showing a strong sense of movement. The lines on the side of the car body are simple and smooth, and the lines on the roof are tilted backwards, creating a dynamic shape. The tail design of the car body is simple and generous, and the taillights adopt a unique through design, which has excellent visual effects. In addition, the Tiggo 9 is also equipped with large-size wheels and sporty wheels to make the whole car look more sporty and fashionable. Overall, the design of Tiggo 9 is fashionable, dynamic and exquisite, and it is a very attractive SUV model.

As a medium-sized SUV, the Tiggo 9 has a length, width and height of 4820*1930*1699mm, a wheelbase of 2820mm, a front track of 1638mm and a rear track of 1641mm, respectively. The side lines of Tiggo 9 are smooth and dynamic, which highlights its sporty atmosphere. The front and rear tyre size are both 245/50 R20, and the tire width is larger, which provides better grip and stability for the vehicle. The rim style is fashionable and matched with the body lines, which makes the appearance of the whole vehicle more fashionable and atmospheric.

The interior design of Tiggo 9 is simple and atmospheric, with black and brown color matching, creating a high-end comfortable atmosphere. The steering wheel is made of genuine leather and feels comfortable. It supports manual adjustment up and down and back and forth, so that drivers can find the most comfortable driving posture. The size of the central control screen reaches 12.3 inches, and the display effect is clear. It supports the voice recognition control system and can control the functions of multimedia system, navigation, telephone, air conditioner and skylight, making it more convenient for drivers to drive. The front and rear rows are equipped with USB and Type-C interfaces for easy charging. The front seats also have heating, ventilation and electric seat memory functions, so drivers can enjoy a more comfortable driving experience. In addition, the second row of seats supports backrest adjustment, and the rear seats can be laid down in proportion, providing passengers with more space and flexibility.

The Tiggo 9 is equipped with a 2.0T 261 horsepower L4 engine with a maximum power of 192 kW and a maximum torque of 400 N m.. This engine can provide abundant power output, so that you can feel a strong sense of acceleration and surging power during driving. At the same time, with the 8-speed automatic manual transmission, the shift is smooth and fast, making driving more comfortable and smooth. No matter on urban roads or highways, Tiggo 9 can easily meet all kinds of driving needs and bring you excellent driving experience.

As a medium-sized SUV, Tiggo 9 has undoubtedly won the favor of the majority of car owners in terms of design. The owner of car home said that the design of Tiggo 9 gives people a very atmospheric and calm feeling, which is neither radical nor unassuming, and it is his favorite design style. This not only reflects the stability and atmosphere of Tiggo 9, but also shows its unique taste and style. It is believed that this design style can meet the needs of more car owners for vehicle appearance and bring more comfortable and confident driving experience to car owners.

　　Source: southern window.

　　"There is a new Great Wall in the north and BYD in the south." At the new car launch in 2022, Li Ruifeng, CGO of the Great Wall, still described the relationship between his family and his friends and businessmen as "North Qiao Feng, South Murong", just like appreciate each other between heroes.

　　But it didn’t arrive in a year, and North Qiao Feng gave South Murong a sneak attack.

　　On the morning of May 25th, Great Wall Motor issued a statement saying that it had submitted materials to the Ministry of Ecology and Environment, the State Administration of Markets, and the Ministry of Industry and Information Technology, and reported that BYD Qin PLUS DM-i and Song PLUS DM-i used atmospheric fuel tanks, which were suspected of failing to meet the emission standards of evaporative pollutants from the whole vehicle.

　　A few hours later, BYD made a statement saying that it resolutely opposed any form of unfair competition and reserved the right to legal proceedings. BYD said that the test vehicle submitted by Great Wall did not meet the requirements of the national standard, and that its test report was invalid.

　　One is the abdicated crown, and the other is the popular new king. The Great Wall’s tip-off letter to BYD, like a hero’s post widely distributed all over the world, made the auto market, which was already in dispute with blood and rain, stir up waves again.

　　Report what?

　　If you want to understand this matter deeply, you need to first interpret the core of the Great Wall report letter, that is, the problem that "the atmospheric oil tank is suspected of causing the evaporation pollutant discharge to fail to meet the standard".

　　Generally speaking, ordinary cars can use an atmospheric fuel tank. The fuel in the atmospheric fuel tank is controlled by atmospheric pressure and can be delivered to the engine by gravity or fuel pump.

　　This kind of oil tank is generally made of plastic and designed to work at atmospheric pressure. The internal and external environment are kept at the same pressure, and the positive pressure is 4~7Kpa.

　　However, for some hybrid vehicles, high-pressure fuel tanks are needed for the sake of emission standards.

　　Because compared with fuel vehicles, the engine of hybrid vehicles is not used frequently, and gasoline is very volatile. If it is not used often, it will accumulate a lot of oil and gas over time and easily escape.

　　Don’t underestimate these vaporized gasoline. The data show that fuel evaporation emissions account for about 20% of light vehicle emissions, which is one of the important sources of air pollution. The "National Six" emission standard has strict requirements on the fuel evaporation control system of automobiles, which makes hybrid vehicles need to solve this problem.

　　As a result, the high-pressure fuel tank came into being. In the high-pressure fuel tank which can bear pressure of 35~40Kpa, oil and gas will remain in the fuel tank under high pressure, and will enter the manifold through the carbon canister when the engine is running, thus reducing the emission of fuel evaporation.

　　BYD Qin PLUS DM-i and Song PLUS DM-i belong to hybrid vehicles. Facing the emission demand, high-pressure fuel tanks may be needed to prevent oil and gas from escaping.

　　After explaining the reporting point, let’s see if it is possible for BYD to use the atmospheric fuel tank.

　　According to common sense, Great Wall Motor obviously has some evidence in its hands when it reports with such fanfare. In BYD’s response, it did not deny the use of atmospheric fuel tanks, explaining that the mileage of the test vehicles that focused on the Great Wall was insufficient, and it was the point that the test report was invalid.

　　Due to the requirements of high-pressure fuel tanks for pressure resistance, the materials of such fuel tanks are mostly steel fuel tanks or encrypted plastics, and the matching fuel cap, fuel filling pipeline and evaporation pipeline also need to be specially made, and the cost is higher than that of atmospheric fuel tanks.

　　From the point of cost reduction, BYD does have the motivation to use atmospheric fuel tanks.

　　However, the hybrid vehicle using atmospheric fuel tank does not necessarily fail to meet the standard of fuel evaporative emission, which needs further testing and verification by relevant departments.

　　The reason why BYD played "3,000 kilometers" actually has a saying.

　　Qin PLUS DM-i and Song PLUS DM-i, as plug-in hybrid cars, have versions with a battery life of more than 100 kilometers. If you only run the "450-670 km" in BYD’s response, there is a high probability that a box of oil has not been run.

　　If a tank of oil is not run out, the frequency of natural internal combustion engine is not high. If it is left standing for a period of time and not kept and sent for inspection within the specified time, the test results may be biased and cannot objectively reflect the emission values of vehicles.

　　Therefore, just looking at the first round of confrontation, the Great Wall only hammered BYD’s "atmospheric fuel tank", but it was temporarily unable to hammer BYD’s emissions.

　　Why today?

　　There is an interesting detail in the tip-off. Great Wall reported BYD on April 11th, one and a half months earlier than May 25th.

　　Why is it so late? Is it because the two sides have communicated beforehand? Or did the Great Wall ever think about keeping a low profile?

　　Perhaps none of the above reasons, but more likely because BYD’s new car Song Pro DM-i Champion Edition is scheduled to be released on the afternoon of May 25th.

　　On the day when the car was replaced, it was "disgusting" to have friends and businessmen, and the "sneak attack" of the Great Wall was well prepared.

　　Hammer you, although it didn’t reach the so-called "filing" in the report letter, the invisible damage caused is really real. It will change consumers’ minds invisibly-that is, BYD’s products are controversial and may have the behavior of "cutting corners".

　　Even if these things are proved to be untrue in the end, this cognitive change has caused a negative impression.

　　It doesn’t matter if you have any questions. But it’s important for consumers to feel "you have a problem".

　　The so-called business war is to attack the minds of consumers.

　　Of course, BYD’s response is also very interesting.

　　The whole response, eight paragraphs, seven exclamation points, an average of nearly one paragraph. The last three paragraphs, or even a single sentence into paragraphs, each sentence has an exclamation point. Anger and grievances are almost overflowing.

　　The last sentence is even more straightforward. "I hope everyone will do more things that are beneficial to the industry and the China brand!"

　　The implication is that what Great Wall has done is harmful to both the industry and the China brand.

　　Since you attacked first, don’t blame me for being rude.

　　In the past, the hero cherished the hero’s "North-South Double Heroes", thus breaking away. This situation reminds people of the kind advice of a 69-year-old veteran comrade-Wulin should value peace, emphasize martial arts and not engage in infighting.

　　Frankly speaking, last year’s metaphor of the Great Wall actually raised its own worth and secretly degraded BYD.

　　Today’s China auto market is no longer the era when Haval H6 dominated the world. Although the Great Wall is still in the first echelon of auto companies, it is far behind by BYD.

　　In 2022, BYD sold 1,863,500 new cars, with an operating income of 424.061 billion yuan, a year-on-year increase of 96.2%. The net profit attributable to shareholders of listed companies was 16.622 billion, up 445.86% year-on-year.

　　In contrast, the Great Wall sold only 1,061,700 new cars last year, with a total operating income of 137.34 billion yuan, a slight increase of 0.69% year-on-year; The net profit attributable to shareholders of listed companies was 8.266 billion yuan, a year-on-year increase of 22.90%.

　　For BYD, 2022 is undoubtedly a bumper year. It has become the champion of its own brand, the champion of global new energy vehicles, and the champion of China automobile market, and it has won many "firsts".

　　The Great Wall is still in a difficult transition in the switch between the old and new markets. The sales target of "1.9 million vehicles" set in 2022 was less than 60%. The sales of Haval, Wei Pai, Euler and pickup trucks under its control fell across the board, while the sales of new energy vehicles declined from 139,000 to 132,000 compared with the previous year.

　　If you don’t want to describe them as Qiao Feng and Mu Rongfu, you have to change your position, and you have lost Mu Rongfu after Wang Yuyan.

　　What I did was big brother

　　Many people believe that BYD’s rise is based on new energy sources.

　　This sentence is correct, but it is not detailed enough.

　　Pure trams are new energy, and hybrid cars are also new energy. The most important thing about BYD’s strong rise in the past two years is that plug-in hybrid vehicles have gained wide market recognition.

　　In 2021, BYD successively launched three models: Qin PLUS DM-i, Song PLUS DM-i and Tang DM-i, which achieved the coverage of the mainstream price range of 100,000-200,000.

　　As a result, in the second year, sales broke out. BYD sold 946,200 hybrid cars, accounting for 50.94% of the total sales. The sales volume of BYD Song PLUS DM-i alone was as high as 380,000.

　　The same thing happened in the whole China market. In 2022, the sales growth rate of plug-in hybrid vehicles reached 150% year-on-year, and the growth rate of ultra-pure electric vehicles was 82%.

　　Plug-in hybrid cars with green license, exemption from purchase tax, subsidy and electricity saving are the "wealth code" of China auto market.

　　Great Wall Motor certainly saw through this. Although it started later than BYD, it soon joined the research and development of hybrid technology. In 2018, Great Wall Motor developed a new hybrid platform, which is now the lemon hybrid DHT system.

　　However, consumers who know that "the Great Wall is also very mixed" are far from knowing that "BYD is very mixed". The reason is that the "coffee series" of the Great Wall really sells badly.

　　On the one hand, the positioning of Macchiato DHT is slightly higher than that of Song PLUS DM-i, and the entry version is 20,000 yuan higher; On the other hand, the naming of "Macchiato" is controversial, which leads to its poor market recognition. In the end, due to the small sales volume, consumers can’t perceive the hybrid technology of the Great Wall, which makes the Great Wall lose its first-Mover advantage.

　　If this technology had been devolved to Haval H6 earlier, it is likely that the current SUV hybrid market is by no means a monopoly of Song Plus DM-I.

　　The former Haval H6, which has won the championship for 100 consecutive months, is a well-deserved "magic car" in China. Until January of 2022, Haval H6 was still the dominant player in SUV field.

　　Unfortunately, it was not until mid-August of 2022 that the mixed version of Haval H6 came late. At this time, the sales volume of H6 has fallen to the fifth place, and not only Song PLUS has surpassed it, but also Yuan PLUS has surpassed it.

　　The failure to grasp the mixed outlet is an important reason why the Great Wall is now trapped in transformation and its sales volume has fallen sharply. I want to make the brand high-end and new energy at the same time, and finally the Great Wall of "one fish and two meals" failed to do both things well. Looking back, this is undoubtedly a strategic mistake of the Great Wall.

　　Although there are many consumers who sing the Great Wall, from the market value point of view, Great Wall Motor with a volume of 210 billion+is still the "second brother" after BYD.

　　This time, the "second brother" challenged the "big brother". Although it is somewhat embarrassing, it is also the norm in business competition.

　　Aboveboard peer supervision also protects the interests of consumers to some extent. If there is unfair competition, I believe that the relevant institutions will eventually give the enterprise an innocence and give a statement after verification.

　　

Fast technology January 19 news, a few days ago, Xiaomi CEO Lei Jun released a video, personally taking everyone to immerse themselves in Xiaomi’s first car Xiaomi SU7.

As you can see,Lei Jun unlocked the vehicle through Xiaomi Watch, and at the same time, the tail wing also rose synchronously, which was very handsome.

After Lei Jun enters Xiaomi SU7 and starts, the main driver’s seat will be automatically adjusted to the memory position. The advantage of this function is that it is convenient to get on and off.

Xiaomi SU7 is also equipped with a dashboard that supports automatic flipping.Support to display total mileage, gear, driving mode and total energy consumption.

Finally, Lei Jun also demonstrated the head-up display function in the car, which can display information such as remaining power, speed and navigation.

The watch is unlocked, the tail wing is automatically raised, the main driver is automatically adjusted, and the dashboard is automatically turned over. It must be said that these processes in one go have already filled the sense of ceremony before Xiaomi SU7 runs.

It is worth mentioning that some netizens sincerely asked Lei Jun in the comment area: Will there be Redmi cars? ".

In this regard, Lei Jun replied: At present, we are still focusing on Xiaomi Automobile. "

It is understood that the first models of Xiaomi SU7 will be equipped with Xiaomi super motors V6 and V6s, with a speed of up to 21,000 rpm, and adopt a new super 800V silicon carbide high-voltage platform developed by Xiaomi, with a maximum voltage of up to 871V V.

(reporting)

　 　 　 　Luo Jing, the host of the famous News Network, Cindy Lee, the actor who plays Fang Yu in Deep Rain, and Fuck off! Tumor jun touched many netizens’ cartoonist Xiong Dun … In recent years, many celebrities have passed away because of lymphoma. At the same time, however, there are also many famous people who have succeeded in fighting cancer after suffering from lymphoma. For example, the 70-year-old famous director Wu Yusen was diagnosed with large B-cell lymphoma in tonsils when filming Taiping Wheel in 2008. After four operations, in the second month of chemotherapy, his mouth was all festered, he could not swallow, and his body and face were so thin that he was wrinkled. Finally, he succeeded in fighting cancer with his firm will! 　

　 　 　 　For example, Kai-Fu Lee, the founder of an innovative factory that successfully used chemotherapy and targeted therapy to fight advanced lymphoma! On September 5, 2013, 52-year-old Kai-fu Lee announced that he had stage IV follicular lymphoma and had to leave work for treatment. In February 2015, he announced the results of his physical examination, indicating that the tumor in the body is not obvious at present. In June of the same year, Kai-fu Lee said that he had not found any lesions in his last two examinations and ridiculed himself as "Li Kangfu". It took Kai-fu Lee less than two years from finding out the cancer until the focus was completely gone. His anti-cancer experience is worth learning from.

Alias "the most disguised disease", lymphoma has become a killer.

　 　 　 　According to statistics, there is a new case of lymphoma every 9 minutes in the world. The incidence of lymphoma in China is 0.02‰, with about 25,000 new patients and nearly 20,000 deaths each year. The threat of lymphoma is rapidly emerging. It ranks among the top ten malignant tumors in China and ranks second among hematological malignancies. At the beginning, the symptoms of the disease were hidden, and it was described as "the most disguised disease". In the intercontinental area, the incidence of non-Hodgkin’s lymphoma is much higher than Hodgkin’s disease, which is about 9: 1. Because of the higher degree of malignancy and worse prognosis, lymphoma is generally referred to as non-Hodgkin’s lymphoma. In China, the incidence of malignant tumors ranks ninth among men and tenth among women. Non-Hodgkin’s lymphoma can occur in all ages, and the high incidence age is 45~60 years old. Among them, Luo Jing suffered from diffuse large B-cell lymphoma (DLBCL). This is a common non-Hodgkin’s lymphoma, which belongs to aggressive lymphoma with high malignancy. The course of the disease progresses rapidly. If it is not actively treated, the median survival time is less than one year. In recent years, great progress has been made in the research and treatment of lymphoma, and new drugs and technologies have risen strongly! CAR-T therapy Among them, the chimeric antigen receptor T(CAR-T) cell therapy is particularly prominent. Its appearance represents a great progress in personalized cancer treatment, especially bringing the hope of rebirth to patients with hematological malignancies.

Complete remission! The first advanced lymphoma patient in China who received CAR-T therapy was discharged smoothly!

　 　 　 　Although they all suffer from diffuse large B-cell lymphoma, Mr. Chen, who suffers from malignant lymphoma, is a lucky one. According to Jiangsu public news channel News Space Station, on August 31st, the first lymphoma patient treated with CAR-T cells in China achieved complete remission and was discharged smoothly. 　

　 　 　 　Mr. Chen suffered from diffuse large B-cell lymphoma. After the onset of the disease in October 2010, he had received chemotherapy for many times, but all of them were unsatisfactory. Diffuse large B-cell lymphoma is the most common malignant lymphoma. After immunotherapy, about 60% patients can survive for a long time, but 40% patients will still relapse. In June this year, Mr. Chen accepted CAR-T cell therapy with a tentative attitude, and all the physical indicators tended to be normal. He told reporters with delight that his physical condition was better than before, and he was no different from a normal person after leaving the hospital. CAR-T therapy, a "living drug", made her completely relieved and looked forward to a cancer-free future.　

　 　 　 　As a "living" drug, CAR-T therapy is very different from traditional drugs. First, the therapy needs to isolate T cells from patients and modify them with chimeric antigen receptor (CAR) in vitro, so that they can specifically recognize cancer cells. Finally, the modified T cells are expanded and reinfused into patients. Compared with traditional chemotherapy and hematopoietic stem cell transplantation, it can kill tumor cells more accurately, improve the curative effect and greatly reduce the side effects. 　

The well-known director of hematology in China said: CAR-T can identify lymphoma very deliberately, and the antigen carried on tumor cells will attack directly after being connected, and it will produce an anti-tumor effect and kill it directly without the need for second signal stimulation, so one of its characteristics is accuracy, and the second is power. The scope of application is still the recurrence or refractory diffuse large B lymphoma that is ineffective in general immunochemotherapy. 　

CAR-T therapy FDA approved 6 models, and domestic CAR-T therapy caught up! 　　　

　 　 　 　After sharing the above news reports about CAR-T therapy, let’s get down to business and talk about CAR-T therapy. At present,CAR-T therapy has achieved great success in the treatment of hematological malignancies.. Six CAR-T cell therapies have been approved by FDA in the United States and two CAR-T cell therapies have been listed in China. The picture below shows CAR-T cell therapy that has been listed at home and abroad. 　 　　

　 　 　 　Although China’s CAR-T technology started late, the domestic market is large. According to the data on Clinicaltrials.gov’s website, China became the country that registered the most CAR-T tests in September 2017. As of May 27th, 2021, there are 1301 CAR-T clinical trials in the world, and the number of CAR-T trials registered in China has reached 478!　

01　　The first CAR-T therapy in China was approved for listing! China welcomes the first year of cellular immunotherapy.

　 　 　 　On June 22nd, the blank in the field of CAR-T in China was finally broken! The latest announcement of China National Medical Products Administration (NMPA), Fosun Kaite Biotechnology Co., Ltd. (hereinafter referred to as " Fosun Kate ”） The CAR-T cell therapy product targeting CD19, Aquilencel Injection (also known as Aquilencel, FKC876), was officially approved for marketing. This is the first approved CAR-T therapy in China and the sixth approved CAR-T therapy in the world. It is believed that China will usher in the blowout era of CAR-T cell therapy.　

02　　In just one month, the second CAR-T therapy in China and the sixth CAR-T therapy in the world were approved!

　 　 　 　On September 3, the State Drug Administration recently announced that Yaoming JunuoThe CAR-T product targeting CD19, Regiosai Injection.(relma-cel, trade name: Benoda) has been officially approved. The approved indications for Regioside Injection are:It can be used to treat relapsed or refractory large B-cell lymphoma (r/r LBCL) in adult patients after second-line or above systemic treatment.Reggiorense injection is the second CAR-T product approved in China and the first CAR-T product of Class 1 biological products in China.

　

It’s only been about one month since it was submitted for examination and approval on July 30th last time, which can be described as rapid progress. Congratulations! (At present, patients with economic conditions can contact cancer-free homes for the treatment of regiorense. )　

Boom! The first BCMA CAR-T therapy in China and the second in the world was approved by FDA!

　 　 　 　China’s "dark horse" in CAR-T cell therapy industry-legendary BCMA(B-cell mature antigen) CAR-T therapy Cedar-B38m/JNJ-4528 (hereinafter referred to as cilta-cel) has attracted much attention, and has shown excellent anticancer activity in clinical trials for multiple myeloma.

　 　 　 　What is exciting is that on February 28th, 2022, local time, it was jointly developed by Janssen and Legendary Biology.BCMA CAR-T product, Cedactylosin (trade name Carvykti), has been approved by the US FDA for the treatment of adult patients with relapsed/refractory multiple myeloma (MM).

This is the first cell therapy product approved by FDA in China and the second CAR-T cell immunotherapy approved for BCMA in the world.

　

　 　 　 　Cilta-cel was awarded priority review qualification by FDA on May 26th.However, the approval of the West Dachiorensai was delayed, and it was adjusted from November 29, 2021 toFebruary 28, 2022Fortunately, it was finally approved and lived up to expectations!

　 　 　 　cilta-celIt is a CAR-T therapy directed by research B cell maturation antigen (BCMA), which is used to treat relapsed or refractory multiple myeloma (RRMM). These patients received an average of five kinds of pre-treatment before treatment, 76% of them received five kinds of treatment, and 86% of them were resistant to five kinds of treatment, including CD38 treatment, and they were both resistant to protease inhibitor PI and immunomodulator IMiD. Simply put, it is refractory to relapse and lack of effective treatment in the follow-up. The principle of this CAR-T therapy is different from the current PD-1/L1. It directly uses the T cells in the patient’s body, transforms them in vitro, replicates them in large quantities, and then transfuses them into the patient’s body to kill cancer cells. At the ASH conference in 2021, the latest results of the 1b/2 CARTITUDE-1 study (n=97) showed that,meso-position 22 months Long-term follow-up, The objective remission rate (ORR) reached 98% , 83% patients achieved strict complete remission (sCR) It is emphasized that the mitigation will deepen with the passage of time (sCR will increase from 67% reported at the ASH annual meeting in 2020 to 83%). At 18 months, 66% of the patients were alive and the disease did not progress. .The two-year progression-free survival rate and overall survival rate are respectively 61% and 74% .The latest research results to be announced at the ASCO annual meeting in 2021 show that After a median follow-up of 18 months, the overall survival (OS) rate was 81%. The remission rate is comparable in all pre-specified subgroups and patients with different treatment lines.

　　 　

American research shows that cilta-cel has excellent long-term efficacy.　 　

　 　 　 　Emily, a foreign country, successfully ushered in nine years of cancer-free survival in 2021, and suddenly became the "spokesperson" of global CAR-T therapy. In China, there is such a lucky person whose fate has been completely changed by CAR-T therapy. Mr. Min was diagnosed with a special rare disease at the age of 54- multiple myeloma . He had no drugs available at that time, so he was lucky enough to participate in the clinical trial of CAR-T therapy. Although the treatment process was not smooth sailing, after three times of treatment, all the lumps on Mr. Min’s body disappeared and the pain disappeared. Surprisingly, by June 4, 2021, Mr. Min had lived cancer-free for five years, which is the field of cancer treatment, which is theoretically said. Clinical cure .

　 　 　 　In fact, as early as March 27th this year,The FDA approved the first CAR-T therapy targeting BCMA for adult patients with relapsed/refractory multiple myeloma (r/r MM) after receiving more than four therapies.

　 　 　 　Chemotherapy to fight cancer is often "killing one thousand enemies and losing eight hundred". Antibody drugs can accurately find tumor targets, but sometimes their combat effectiveness is insufficient. If we can put a "warhead" of chemotherapy drugs on antibody drugs, can we attack cancer cells more accurately? Based on this, an ADC (antibody drug conjugate) called "biological missile" was born. Antibody-coupled drugs are like biological missiles, which consist of two core functions: the first is antibody (missile body), the second is strong chemotherapy drug (nuclear warhead); This design will enable antibodies to find tumor cells with chemotherapy drugs, and then accurately poison tumor cells and poison them. 　This drug design combines the precision of targeted drugs with the high efficiency of chemotherapy drugs, which not only avoids the toxic and side effects of systemic use of chemotherapy drugs, but also has stronger killing ability than using targeted drugs alone, killing two birds with one stone. 　 　 　 　

Schematic diagram of antibody-coupled drugs 　 Note: (a) General description of A)ADC structure; (b) the mechanism of B)ADC. 　

Fourteen ADC drugs have been approved around the world, which brings hope for prolonging the survival time of back-line patients.

　 　 　 　At present, more than 100 kinds of ADC are undergoing clinical trials. Most adcs have progressed from phase i to phase II. Some ADC phase III trials show positive results; Up to September 20th, 2021, there are 14 kinds of ADC drugs on the market in the world, which are mainly used in hematological tumors and solid tumors, and are mainly used for back-line treatment of patients, including advanced, recurrent/refractory and metastatic tumor indications.

　

Fourteen ADC drugs have been approved worldwide.

According to the curative effect data, ADC drugs have brought more treatment options and the hope of prolonging the survival time for back-line patients, and the objective remission rate or median progression-free survival time of several drugs has doubled compared with chemotherapy.

Looking at the CD30 target, the new drug F0002-ADC became an instant hit and squeezed into the lymphoma track.

　 　 　 　CD30, a member of tumor necrosis factor (TNF) receptor superfamily, can promote cell proliferation or apoptosis by activating different signal pathways. In 2020, Vebtuximab for injection (Adcetris) was approved to be listed in China, and CD30 became famous. Adcetris, as an antibody-coupled drug targeting CD30, has an effective rate of 73% for Hodgkin’s lymphoma (HL) and 86% for anaplastic large cell lymphoma (ALCL). It is the first new drug approved in the field of Hodgkin’s lymphoma treatment in recent 30 years, and it is also the first time that a drug targeting CD30 has been approved, filling the gap in this field. At present, the only new ADC drug for CD30 in China is F0002-ADC. This new drug consists of three parts, namely, human-mouse chimeric anti-CD30 monoclonal antibody, thioether linker (MCC) and DM1. Since the project was launched in 2016, it has been disappointing! At present, patients with recurrent/refractory CD30 positive peripheral T-cell lymphoma are being recruited clinically! This is a new treatment option for patients with recurrent/refractory peripheral T-cell lymphoma!

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